FmMiRNADb (Foxtail millet micro RNA database) is the first online database
of microRNA (miRNA) sequences, its annotation and secondary structure for the
model crop Setaria italica L..
miRNAs play a prominent
role in gene regulation during multiple biological processes including stress response, through
post-transcriptional control. Foxtail millet, the second largest cultivated millet species has been recently
considered to be a tractable model crop for studying functional genomics, as it possesses a small genome
(~515 Mb), short life-cycle, rich genetic diversity (~6,000 varieties), inbreeding nature and closely-related
to several bioenergy grasses. Recently, the draft genome sequence
was released by US Department of Energy - Joint Genome Initiative and Beijing Genomics Institute, China.
Being a potential abiotic stress tolerant crop, foxtail millet is also used as model to decipher the molecular
mechanism involved in tolerance towards abiotic stresses such as
drought and salinity.
Hence, our group conducted a genome-wide investigation to identify
the miRNAs and our study reported 355 mature miRNAs to be encoded by the foxtail millet genome. Further, all the
355 miRNAs were annotated and its respective secondary structures were predicted. Noteworthy, from these
355 miRNAs, 123 primer pairs were developed as miRNA-based molecular markers and 24 of them were validated in a
set of foxtail millet accessions.
With a view of providing the information generated on miRNAs to the plant research community, this FmMiRNADb
was constructed. Currently, this database encompasses all the details of 355 Setaria italica miRNAs
including its molecular characteristics, sequences, annotation, physical position, secondary structure and
comparative genome mapping information between the physically mapped miRNAs of foxtail millet and sorghum, maize,
rice and Brachypodium. In addition, the database also harbors the 123 miRNA-based molecular markers developed in
The design of FmMiRNADb database schema follows the "Three-Level-Schema" architecture, is shown in
figure 1, developed using open-source softwares,
The FmMiRNADb schema is shown in the figure 2.
Go to "Browse" tab on home page to start using FmMiRNADb.